CXCL10, also known as interferon-inducible protein-10 (IP-10), a member of chemokine family, was one of the down-regulated platelet proteins in dogs with acute CHF in the present study, similar to the results of serum CXCL10 in mice with myocardial infarction [46]. The gene discussed is CXCL10; the disease is congestive heart failure.