Patients with DFU exhibited elevated ANGPTL2 levels when compared to subjects with T2DM only (T2DM vs. DFU: 4.221 ± 1.301 vs. 6.561 ± 2.335 μg/L, p < 0.0001) (Fig. 1). This evidence concerns the gene ANGPTL2 and type 2 diabetes mellitus.