In the model, after adjustment for the age, sex, history of T2DM, and HbA1c, which are common risk factors for diseases, the data suggested that ANGPTL2 was an independent risk factor for DFU (β = 1.2759, OR (95% CI): 3.58(1.81–7.10), p = 0.0003). The gene discussed is ANGPTL2; the disease is type 2 diabetes mellitus.