Khattab et al. [30] found that AdipoQ levels in HCC with the size of nodules≥5 cm were significantly higher than<5 cm (24.2 ± 2.1 vs 20.8 ± 3.8, P = 0.009), whereas, AdipoQ levels were not related to TNM stages, number of nodules and lymph node metastasis. This evidence concerns the gene ADIPOQ and hepatocellular carcinoma.