Al-Gayyar et al. revealed that AdipoQ can completely prevent the increase of HCC-induced sulfatase-2, improve HCC-induced tumor invasion markers, matrix metalloproteinase 9, syndecan-1 and fibroblast growth Factor-2 induced by HCC, decrease the expression of NF-κB and tumor necrosis factor α (TNF-α) induced by HCC, to achieve liver protection [69]. This evidence concerns the gene ADIPOQ and hepatocellular carcinoma.