During D10–13 post-bacteremia, TNF-α, IL-10, and IL-6 levels were significantly higher in patients with persistent bacteremia than in patients whose SAB resolved in 4 d (TNF-α: 10.41 [4.23–17.14] vs 4.36 [3.31–9.39] pg/mL, p = 0.038; IL-10: 2.69 [1.71–4.92] vs 1.18 [0.68–2.10] pg/mL, p = 0.038; IL-6: 17.54 [6.58–31.68] vs 6.49 [2.85–12.62] pg/mL, p = 0.018). This evidence concerns the gene IL6 and bacterial infectious disease with sepsis.