AGTR1 and Hypertension: In general, the renin-angiotensin system induces vasoconstriction, hypertension, inflammation, fibrosis, and proliferation via the ACE/angiotensin II/angiotensin II type 1 receptor (AT1R) axis and induces the opposite effects via the ACE2/angiotensin (1–7)/Mas axis function [15,16].