EGFR and cyst: Autosomal dominant polycystic kidney disease (ADPKD) represents the most prevalent (1/1000–1/2500 live births) genetic disease affecting the kidney, resulting in a massive cystic enlargement of renal tubules caused by an enhanced epithelial cell proliferation, altered fluid secretion, changes in the extracellular matrix, extrarenal alterations, and mispolarization of several membrane proteins such as the epidermal growth factor receptor (EGFR) leading to cyst formation in both kidneys [1,2].