TSC1 and neurodevelopmental disorder: Moreover, a subset of single gene mutations associated with ASD are also responsible for other neurodevelopmental disorders, including fragile X mental retardation syndrome 1 (FMR1) in fragile X syndrome, tuberous sclerosis 1(TSC1) in tuberous sclerosis, and methyl-CpG binding protein 2 (MECP2) in Rett syndrome [11].