F3 and neoplasm: We have developed a new class of bifunctional proteins which anchor an essential procoagulatory molecule—tissue factor (TF)—into tumor vessels via C-terminal binding-motif peptides to induce selective tumor vascular occlusion and infarction [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21].