Gellert-Kristensen et al. combined three NAFLD-related SNPs in PNPLA3, TM6SF2, and HSD17B13 and showed the association with HCC by comparing with the general population (OR, 29.0 for the highest risk group compared to the lowest risk group), although application in the general population is unlikely [66]. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.