PNPLA3 and fatty liver disease: The PNPLA3 I148M was also associated with a high liver-related mortality in a large population study and liver cancer-related mortality in patients with NAFLD in the US [101,102] Further, this variant may be associated with HCC risk after achieving SVR with DAA, [103,104] presumably reflecting the association between HCV infection and hepatic steatosis [105].