Figure 7 shows the expression of cytokines regulated by ML extracts. The control group subjected to CRS showed increased expression of IL-1β mRNA, a pro-inflammatory cytokine; we confirmed that it was decreased in a dose-dependent manner by ML extracts. On the contrary, the mRNA expression of the anti-inflammatory cytokines IL-4 and IL-10 tended to be reduced by stress in the control group, while it was significantly increased by the ML extracts. The gene discussed is IL10; the disease is congenital rubella syndrome.