Notably, memory and cognitive alterations not only in animal models of depression but also in humans with X-linked mental retardation are characterized by impairments in OPHN-1 transduction and translation [6,37] supporting the possibility that chronic phytosome administration, by increasing OPHN-1 translation, could induce an enhancement in brain mechanisms crucially involved in cognitive processes. This evidence concerns the gene OPHN1 and major depressive disorder.