To investigate if VACV ANCHOR responds to HDAC inhibitors, we determined the effect of Vorinostat [23], a HDAC inhibitor used in the clinic, on the infection rate and replication level of VACV ANCHOR in the fibroblast MRC5 cell line and in the cancerous HCT116 cell line (Figure 4B,C). This evidence concerns the gene HDAC9 and infection.