Studies by Tomita et al. demonstrated several breast cancer cell lines expressing various p53 mutants failed to form complexes with Bcl2 in MDA-MB-231 (p53 R280K), MDA-MB-468 (p53 R273H), T47D (p53 L194F), and SKBr3 (p53 R175H) cells when compared to ML-1 (wtp53) cells [65]. The gene discussed is TP53; the disease is breast cancer.