Similarly, Wang et al. demonstrated in HCC cell lines that exposure to fangchinoline, a bisbenzylisoquinoline alkaloid shown to induce cell cycle arrest in breast and prostate cancer cell lines [170], induced autophagy in a p53/sestrin2/AMPK-dependent manner and induced autophagic cell death in HepG2 and PLC/PRF/5 cell lines [171]. The gene discussed is TP53; the disease is hepatocellular carcinoma.