TP53 and neoplasm: It has also been shown that p53 mutants are able to actuate various survival signaling cascades, such as the NF-κB, PDGFRβ, mevalonate, proteasomal, or integrin pathways [28,29,30,31], and activate an independent set of target genes in cooperation with other transcription factors or cofactors (such as Pin1 [32] and PML [33] proteins), thereby promoting tumor cell survival and/or proliferation.