Interestingly, in a mammalian breast cancer model, piperine had a broad inhibitory effect on both G1/S and G2/M transition, confirmed by the upregulation of cell division cycle 25C (CDC25C) [28], which is a phosphatase involved in both of the aforementioned transitions, and the downregulation of cyclin B, but not cyclin D [25]. The gene discussed is CDC25C; the disease is breast cancer.