Interestingly, piperine suppressed the expression of fatty acid synthase through the inhibition of extracellular signal-regulated kinase 1/2 (ERK1/2) and the reduction of mature sterol regulatory element-binding protein-1 (SREBP-1), leading to apoptosis in HER2-overespressing breast cancer cells [26]. This evidence concerns the gene ERBB2 and breast carcinoma.