The inhibition of cancer cells’ migration by piperine via EMT suppression was recently demonstrated in colon cancer cell models [40], where piperine reduced the phosphorylation of STAT-3 and the expression of the EMT regulator Snail, whose inhibition is accompanied by upregulation of the epithelial marker E-cadherin and downregulation of the mesenchymal marker vimentin [40] (Table 2). This evidence concerns the gene STAT3 and cancer.