PDK2 and osteoporosis: Ovariectomy, a procedure that induces estrogen-dependent osteoporosis, of Pdk2 null (Pdk2−/−) mice show reduced osteoclast number, suppressed osteoclastogenesis, and suppressed bone resorption through the RANKL‒CREB‒c-Fos‒NFATc1 pathway [135].