COL2A1 and neoplasm: Interestingly, normalization of upregulated intracellular cholesterol synthesis in Col2a1-CreERT2;Idh1R132Q/R132Q mice by loss of Scap (Col2a1-CreERT2;Idh1R132Q/R132Q;ScapF/F mice), or by treatment with lovastatin, suppresses chondrogenic tumor growth [87].