DHCR7 and Smith-Lemli-Opitz syndrome: As described above, there are differences in the clinical features of the syndromes (e.g., lathostelosis, SLOS, and desmosterolosis) as well as in the phenotypes of Sc5d−/−, Dhcr7−/−, and Dhcr24−/− mice, suggesting that the accumulation of different cholesterol intermediates contributes to the pathogenesis of these diseases, rather than the absence of mature cholesterol [78].