TGFB1 and multiple self-healing squamous epithelioma: In silico modeling of the extracellular domain of the TGFβ signaling complex shows that most missense variants found in MSSE patients result in amino-acid substitutions affecting residues that lie along the interface at which TGFβRI interacts with the previously assembled TGFβRII and TGFβ or at the interface at which TGFβRI interacts TGFβ directly [9].