TGFBR1 and keratoacanthoma: A 56 year old man with a five year history of keratoacanthomas over his arms, face and scalp was found to be carrying a TGFBR1 missense variant (c.664G > A, p.(Gly222Arg)), resulting in substitution of a glycine residue by an arginine at position 222 within the serine/threonine kinase domain [15].