TRIM16 and amyotrophic lateral sclerosis: The Mantis-ml ALS model top predicted genes also had an overlap with the genes associated with the top performing promoters predicted by the Promoter-CNN model [90], but only in terms of shared protein families: within the top 8 promoter regions that Promoter-CNN selected for chromosomes 7, 9, 17, and 22, there were two promoter regions that were associated with genes LAMB4 (laminin subunit beta 4) and TRIM16 (tripartite motif containing 16); while among Mantis-ml highest predicted ALS genes were LAMB3 (laminin subunit beta 3) and TRIM28 (tripartite motif containing 28).