TP53 and cancer: GRK5, for instance, exerts a double effect in cancer either as an inhibitor through the desensitization of G Protein coupled Receptors (GPCR) and non-GPCR receptors (TSH, PGE2R, PDGFR) or a trigger through the regulation of non-receptor substrates (p53, AUKA, and NPM1) [2].