Since GRK2 levels and activity are also increased in thyroid cancer tissues [9], here, we assessed such crosstalk in cancer cell lines derived from human thyroid anaplastic cancer: BHT-101, which carries a mutation in the p53 gene which inhibits DNA binding, and FRO, which is a p53-null cell line. Here, GRK2 is linked to thyroid gland undifferentiated (anaplastic) carcinoma.