TBX4 and Pulmonary hypoplasia: Not all patients harbouring deleterious variants in TBX4 fit neatly into Group 1 PH, some individuals with heterozygous mutations in TBX4 or large deletions encompassing TBX4 were characterised by death in infancy secondary to acinar dysplasia [300], congenital alveolar dysplasia and pulmonary hypoplasia [301].