Another large-scale study in a more heterogeneous group of patients (Group 1 PAH) [25] reported BMPR2 mutations in 180 of 2572 cases (7%); the frequency of BMPR2 mutations in FPAH and IPAH patients were 62.4% and 9.3%, respectively. This evidence concerns the gene BMPR2 and heritable pulmonary arterial hypertension.