SOX17 and pulmonary arterial hypertension: To date, the largest PAH GWAS of multiple international I/HPAH cohorts, totalling 2085 cases and 9659 controls, identified two novel loci associated with PAH: an enhancer near SOX17 (rs10103692, OR 1.80 (95% CI 1.55;2.08), p = 5.13 × 10–15), and a locus within HLA-DPA1/DPB1 (rs2856830, OR 1.56 (95% CI 1.42;1.71), p = 7.65 × 10–20) [116].