SIRT3 and idiopathic pulmonary arterial hypertension: In IPAH, a SNP (rs11246020) in the Sirtuin3 (SIRT3), mitochondrial deacetylase, in either homozygote or heterozygote fashion, was associated with increased acetylation of mitochondrial proteins compared to the IPAH patients or disease comparator group with the WT genotype [166].