Although several molecules have some potential clinical values as melanoma biomarkers (lactate dehydrogenase (LDH), tyrosinase, Programmed Cell Death 1 Ligand 1 (PD1L1) and S100B), they also presented some limitations, and for this reason, there is currently no ideal biomarker in melanoma [35,36,37,38]. The gene discussed is CD274; the disease is melanoma.