ARHGEF7 and familial pancreatic carcinoma: βPix/COOL-1 has also been shown to interact with PAK1 (p21-activated kinase) and STIL (SCL/TAL1-interrupting locus), to promote actin remodelling and promote cancer cell migration in pancreatic cancer models [51] suggesting a potential mechanism for the βPix/COOL-1 mediated invasion evident in GBM.