ARHGEF7 and neoplasm: Here, βPix/COOL-1 mRNA expression is significantly upregulated in samples derived from the leading tumour edge (15.57% of samples) compared to samples representing cellular tumour (24.59% of samples) (p = 1.22 × 10−7) and infiltrating tumour (19.67% of samples) (p = 1.446 × 10−6) (Figure 1E).