CD8A and infection: Depletion of CD8+ T cells increased the replication of a Us3 kinase-dead mutant virus at the infection site following footpad infection in mice, compared to a mock depletion, indicating that Us3 protein kinase mediates evasion of HSV-1-specific CD8+ T cells by downregulating MHC class I surface expression and contributes to viral propagation in vivo [25].