To investigate whether endogenous HBc undergoes ubiquitination in the context of the whole HBV genome and other viral proteins, HBV-infected HepG2-hNTCP cells were transiently transfected four days post-infection with an empty vector, i.e., HA-tagged Ub-WT, Ub-K29, or Ub-K29R. This evidence concerns the gene KRT88P and infection.