SLC2A4 and Insulin resistance: Thus, we suggest two main mechanisms by which OLP act on an increase in GLUT4 translocation: β-cell stimulation in the pancreas with ensuing insulin release (regulating the expression of genes associated with insulin secretion and signaling), and insulin-mimetic properties of OLP, which induce the uptake of glucose into muscle and adipose tissue in the absence of insulin or in the presence of insulin resistance.