Thus, we suggest two main mechanisms by which OLP act on an increase in GLUT4 translocation: β-cell stimulation in the pancreas with ensuing insulin release (regulating the expression of genes associated with insulin secretion and signaling), and insulin-mimetic properties of OLP, which induce the uptake of glucose into muscle and adipose tissue in the absence of insulin or in the presence of insulin resistance. The gene discussed is INS; the disease is Insulin resistance.