Although secretion of anti-tumor cytokines CXCL10 and CCL5 (ranking third and fourth in cytokine array) from THP-1 was increased by visfatin treatment, other tumor progression factors triggered by V-THP-1, especially the two top-ranking cytokines CXCL1 and PAI-1 in cytokine array, had a protumor property and led to breast tumor progression eventually. The gene discussed is SERPINE1; the disease is breast neoplasm.