The cross-talk between tumor microenvironment and immune alterations (e.g., T cell-mediated anti-tumor response) indeed influenced tumor progression through many other factors such as IL-1α, IL-10, PD-L1, TNF-α, TGF-β, and CXCL1, 5, 8, 12 [54,55,56], but there was less information about the adipocytokines in this field with consideration of the tumor-immune microenvironment. This evidence concerns the gene CD274 and neoplasm.