However, while the two NPM1-mutated CMML cases described by Courville et al., rapidly evolving to AML, also disclosed FLT3 mutations [40], several further patients with NPM1-mutated non-acute MN diagnosis, experienced AML progression despite the absence of concurrent FLT3 mutations [71,75,79,80,87]. Here, NPM1 is linked to acute myeloid leukemia.