NPM1 and myeloproliferative disorder: Finally, in mice genetically engineered through a dual-recombinase system, Loberg et al. recently described the sequential induction of Dnmt3a mutation, leading to features resembling human clonal hematopoiesis, such as expansion of hematopoietic stem and multipotent progenitor cell compartments, and subsequent induction of mutant Npm1, which then caused progression of clonal hematopoiesis to a myeloproliferative disorder (MPD).