Accordingly, in the study by Vallapureddy et al., NPM1-mutated CMML patients were more likely to be anemic and to have a dysplastic CMML phenotype, compared with NPM1 wild-type counterparts, while an increased incidence of DNMT3A and FLT3 mutations and a lower frequency of TET2 and ASXL1 mutations were observed in NPM1-mutated subgroups [75]. This evidence concerns the gene DNMT3A and chronic myelomonocytic leukemia.