NPM1 and acute myeloid leukemia: In more details, Guryanova et al. recently reported the lack of overt AML development in Npm1cA1+/Dnmt3aR878H compound model, whereas Npm1/Flt3-ITD/Dnmt3a triple-mutated mice invariable succumbed from a particularly aggressive AML, confirming the role of co-mutated genes in dictating whether leukemogenesis does occur or not in murine Npm1-mutated models [107].