IFNA1 and infection: Mice with IFNAR1–IFNLR1 double knockout, as with IFNLR1 knockout alone, were characterized by increased viral loads at 3–5 days after infection, increased levels of pro-inflammatory immune cells in BALF (mainly neutrophils and macrophages), increased pro-inflammatory cytokine and chemokine levels (IFN-α, IL-6, CCL2, CCL3, CXCL1/keratinocyte chemoattractant (KC)), and lung tissue damage.