The core of genes shared by all panels for SNVs (BRAF, CREBBP, CRLF2, EZH2, FLT3, IL7R, JAK1, JAK2, JAK3, KRAS, NF1, NRAS, PAX5, and PTPN11) covered mainly those genes involved in new classification subtypes (such as Ph-like or BCR-ABL1-like, and PAX5 alterations subtypes), which in turn represent new therapeutic targets involved in deregulated cell pathways in ALL [11,12,13,14]. The gene discussed is PAX5; the disease is acute lymphoblastic leukemia.