Similar to NAA10 p.(D10G) and p.(L11R), NAA10 p.(S37P) has been found to impair NatA complex formation and cause reduced Nt-acetylation of some NatA substrates in Ogden-syndrome patient fibroblasts and B-cells. This evidence concerns the gene NAA10 and Premature aging appearance-developmental delay-cardiac arrhythmia syndrome.