LGR5 and hereditary clear cell renal cell carcinoma: In line with that, the in silico analysis of functional relevance of specific gene regions carried out using ENCODE data (Figure 2) indicated that this SNP is located in a candidate cis-regulatory element (cCRE) EH38E2679714 (hg38), which is predicted to have promoter-like signature inter alia in HEK293 cell line (established from primary embryonic human kidney) as well as high DNase signal (characteristics of active gene regulatory elements) in renal cell carcinoma (other data are not available for RCC).