The aim of our study was to evaluate the expression levels of TLR2, TLR3, TLR4, and TLR5 in intestinal biopsy specimens of patients with different histological colorectal polyp types including HP, SSA, tubular adenoma (TA), and villous/tubulovillous (VP/TVP) cases compared to normal controls. The gene discussed is TLR4; the disease is polyp of large intestine.