The aim of our study was to evaluate the expression levels of TLR2, TLR3, TLR4, and TLR5 in intestinal biopsy specimens of patients with different histological colorectal polyp types including HP, SSA, tubular adenoma (TA), and villous/tubulovillous (VP/TVP) cases compared to normal controls. This evidence concerns the gene TLR5 and polyp of large intestine.