Tumor suppressor effects of this miRNA were observed in the case of non-small cell lung cancer via direct targeting of zinc finger E-box binding homeobox 2 (ZEB2) and inhibition of the epithelial-mesenchymal transition (EMT) process [22] and by downregulation of matrix metalloproteinase-16 (MMP16) expression [23]. The gene discussed is MMP16; the disease is neoplasm.