Comparisons of pediatric-onset IBD (ALL pediatric subsets; 85 genes) and adult-onset IBD genes (ADULT-1 subset; 240 loci) revealed a small overlap of genes SLC9A3, IL10, STAT1, CARD9, STAT3, CD40, and NCF4. Overlap of loci associated with complex adult IBD, complex pediatric IBD, and monogenic pediatric IBD is displayed in Figure 2. This evidence concerns the gene NCF4 and inflammatory bowel disease.