Another small pilot study conducted by Fujimoto et al. [33] investigated the effects HF10 in subcutaneous metastases of head and neck squamous cell carcinoma in two patients; the authors admittedly described no macroscopic changes two weeks after virus inoculation, but report tumor cell death and fibrosis as well as an enrichment of CD4+- and CD8+-T-cells in the histopathological analyses of resected tumor specimens. Here, CD8A is linked to neoplasm.