LEP and obesity due to melanocortin 4 receptor deficiency: From our findings, we suggest that leptin, which increases with age and obesity in dogs, can stimulate mammary gland cancer metastasis by elongating the half-life and multimerization of LAMP2a. We also demonstrated that Allo-aca can reverse the promotion of EMT and invasiveness of CHMp cells treated with leptin through selective pairing to OBR without any agonistic effects.