Loss of heterozygosity and SNP arrays have shown loss or mutations in tumor suppressor genes such as TP53 (P53) [111], retinoblastoma RB1 (RB1) [112], CDKN2A (P16INK4A) [113], and insulin-like growth factor-2 receptor (IGF-2R) [114]. Here, RB1 is linked to neoplasm.