Research indicates that the increased cardiovascular risk in patients with CKD is multifactorial and involves both conventional (hypertension, diabetes, dyslipidemia) and kidney-specific risk factors, such as enhanced activity of the renin–angiotensin system, sympathetic overactivity, endothelial dysfunction (related to the accumulation of asymmetric dimethylarginine, chronic inflammatory state, and oxidative stress), hyperphosphatemia, and CKD-associated metabolic bone disorder [8,9,10]. Here, REN is linked to chronic kidney disease.