Mature human eosinophils contain crystalloid secondary granules, which are primarily composed of highly charged basic proteins, including two major basic proteins, eosinophil cationic protein, eosinophil-derived neurotoxin, and eosinophil peroxidase, which cause bronchial epithelial damage and nasal obstruction [35,36]. This evidence concerns the gene RNASE2 and Nasal congestion.