Electrostatic forces are predominant drivers for LLPS of intrinsically disordered proteins like tau [107], which is further facilitated by crowding agents, RNA [102], and PTMs, such as phosphorylation [35,108,109], that drive tau loss-of-function, promote aggregation, and present with distinct profiles across tauopathies [48,83,88,108,109]. This evidence concerns the gene MAPT and tauopathy.