Recent breakthroughs in the resolution of disease-associated tau conformations and fibrils have made evident that distinct conformers of monomeric misfolded tau can assemble into aggregates and hydrogen-bonded protofilaments that are packed in different ways to form fibrils that originate unique molecular signatures for each tauopathy, frequently referred to as disease-specific strains [91,92]. Here, MAPT is linked to tauopathy.