Several additional studies have shown evidence of abnormal autophagy-lysosomal function in the brain of tauopathy patients, as well as in animal and cellular models, where accumulation of autophagic vesicles, lysosomes, and tau correlate with neuronal toxicity [152,153,155,157,201,202] and enhanced tau aggregation [203,204]. This evidence concerns the gene MAPT and tauopathy.