HSPA8 and calcification: 7-KC was shown to aggravate VCN by inducing lysosomal dysfunction and autophagosome accumulation [82] Lastly, granzyme B was degraded in hypoxia-induced pulmonary calcification by chaperone-mediated autophagy, characterized by an increase in Heat Shock Protein Family A (Hsp70) Member 8 (HSPA8) and lysosome-associated membrane protein 2 (LAMP2A).