Most LGLL cases derive from TCRαβ+CD4−CD8+ T lymphocytes (TCD8+), less frequently from TCRαβ+CD4+CD8−/+lo T cells (TCD4+), TCRγδ+ T cells (Tγδ+) or NK cells, and rarely from other cytotoxic cells (i.e., TCRαβ+CD4-CD8−/+lo double-negative T cells -Tαβ+DN-) [4]. The gene discussed is CD8A; the disease is T-cell large granular lymphocyte leukemia.