In addition, we also demonstrate for the first time that in most LGLL subtypes, STAT3 mutations are associated not only with a more marked neutropenia (as also has been reported by other authors in TCD8+-LGLL and CLPD-NK) [7,9,20,30,34], but also with overall reduced counts of major normal residual populations of immune cells in blood, independently of the number of coexisting LGL clones. Here, STAT3 is linked to T-cell large granular lymphocyte leukemia.