Zinc deficiency has a dose-dependent response to plasma cytokines, as zinc prevalence affects the production of cytokines, such as interleukins (IL-1β, IL-2, and IL-6) and tumor necrosis factor alpha (TNF-α) by MT homeostasis, which is, in turn, affected by proinflammatory cytokines (Figure 3). Here, IL1B is linked to Zinc deficiency.