The following four pieces of evidence in hypoglycemia-induced neurons were observed: the depletion of zinc from the presynaptic vesicles, the appearance of zinc in the somata of injured hippocampal postsynaptic neurons, the prevention of neuronal injury by the chelation of extracellular zinc, and the prevention of PARP activation by extracellular zinc chelation. The gene discussed is PARP1; the disease is Hypoglycemia.