SOAT1 and autosomal dominant polycystic kidney disease: It should be noted, however, that the use of HIF inhibitors may potentially be limited in ADPKD as HIFs are also essential for making erythropoietin, which in turn instructs an increase of red blood cells, via activating the Janus Kinase and Signal Transducers and Activators of Transcription cascade (more on JAK/STAT below).