Inherited predisposition to acquire PCa is genetically determined by the presence of a deleterious mutation of DNA repair genes also related to breast/ovarian cancers (i.e., BRCA1 and BRCA2, ATM, etc.)or PCa-specific risk genes (HOXB13 and 8q24 region) [10]. This evidence concerns the gene BRCA1 and posterior cortical atrophy.