INS and Hyperglycemia: In patients with and without diabetes admitted to ICU with critical illness and hyperglycemia, on oral or tube feedings, DSNF reduced glycemic variability (12.6% vs. 15.9%, p = 0.01) and insulin utilization (45.0 vs. 107 mean units over the 24-h study period, p = 0.02) compared to a standard control formula [57].