The differentiated cancer model (estrogen+), with a moderate concentration of Vit D supplement, did not exhibit any effects [25,28], exhibited inhibition of tumoral growth accompanied by decreases in the expression of Bcl-2, aromatase, estradiol, and Cox-2 [20], or presented an increase in apoptosis cell content with augmented p53 expression [21]. This evidence concerns the gene TP53 and cancer.