In this regard, the cell-permeable phycotoxin okadaic acid (OKA) [14] has been used to generate the main traits recognized in AD; this phycotoxin induces hyperphosphorylation of tau and the formation of neurofibrillary tangles in vivo in animal models, ex vivo in tissular cultures, or in vitro in dissociated cells [6,15,16]. This evidence concerns the gene MAPT and Alzheimer disease.