APP and Alzheimer disease: These observations are in agreement with the functional themes reported on a separate AD GWAS meta-analysis which concluded that four main GO biofunctions were significantly associated with AD risk: Protein lipid complex; APP catabolic process; High-density lipoprotein (HDL) particle, Protein lipid complex assembly and with lower significance additional lipid-related themes such as Low-density lipoprotein (LDL) particle, Protein lipid complex organization and Chylomicron [61].