In contemporaneous studies, while developing models to study the role of WWOX in cancer, we generated a full Wwox knockout (Wwox-KO) model using mice harboring loxP sites flanking exon 1 of the gene (WwoxloxP/loxP) crossed to mice expressing Cre-recombinase controlled by adequate promoters to obtain whole-body deletion [33]. Here, WWOX is linked to cancer.