WWOX and attention deficit-hyperactivity disorder: These observations emphasize the notion that WWOX, because containing FRA16D, is a hotspot for common germline CNVs and it is precisely this intrinsic fragility that is the cause for the frequent association of WWOX CNVs with neurological and developmental disorders as described here, i.e., WOREE, ASD, ID, and possibly other conditions, such as ADHD.