Analysis of RNA sequencing data from The Cancer Genome Atlas (TCGA) Prostate Adenocarcinoma (PRAD) cohort revealed that KLK4 mRNA levels were significantly lower in specimens of Gleason grade 8 (n = 67) or 9 (n = 142) compared to grade 6 (n = 50) (Figure 1A), and Gleason grade >7 had lower KLK4 transcript levels than Gleason grade <7 (Figure 1B) [9]. The gene discussed is KLK4; the disease is prostate adenocarcinoma.