For example, we have shown that expression of the KLK4 protease could induce an EMT-like phenotype in PC3 PCa cells (mesenchymal phenotype, a reduction in proliferation rate and an increase in cell migration) which is a cellular phenotype often associated with more aggressive disease but also known to lead to a reduction of the primary tumor burden in favor of the formation of metastasis [6,18]. The gene discussed is KLK4; the disease is neoplasm.