We found that AS (beta −1.037, 95% CI −1.479–−0.595, p < 0.001), age (beta −0.555, 95% CI −0.739–−0.371, p < 0.001) and LVMI (beta 0.288, 95% CI 0.017–0.559, p = 0.038) were associated to COX-2 levels at the univariable analysis. Here, PTGS2 is linked to aortic stenosis.