TXNIP and aortic stenosis: Observations of increased levels of thioredoxin-interacting protein (TXNIP), which is suppressed by NO, in a rabbit model of mild aortic stenosis [9], and of increased levels of myeloperoxidase (MPO), a NO scavenger, in stenotic valves [10] are consistent with the hypothesis of an impairment of NO as a mechanism underlying AS [11,12,13].